Instructions for the use of serenia in dogs. Calculate the optimal dose of the drug in dogs. Explore the breadth of the antiemetic effect of serenia in canine medicine. Improve therapy effectiveness by 200%

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• Veterinary drug

• Name of the drug: Serenia (in Latin CERENIA)
• Active ingredient: maropitant citrate
• Neurokinin receptor antagonist (NK1)
• Antiemetic drug for dogs
• Has some anti-inflammatory, analgesic, anti-anxiety, antipruritic and antitussive effects
• Used to treat various pathologies in dogs
• Available in tablets and injection solution
• DOSE: treatment and prevention of vomiting in dogs - injection form 1 mg/kg, oral - 2 mg/kg; motion sickness - 8 mg/kg orally.

Cautions for using Serenia:

Not intended for use in humans. Keep out of the reach of children. Topical exposure to Cerenia may cause local allergic skin reactions in some people. In case of accidental ingestion, consult a doctor. Repeated or prolonged exposure may cause skin sensitization. Wash your hands with soap and water after taking this medicine. Serenia is also an eye irritant. In case of accidental contact with eyes, rinse them with water for 15 minutes and consult a doctor.

Brand name:

• Serenia (Pfizer)

Release form and composition

The veterinary drug Serenia is an innovative antiemetic drug developed specifically for international dogs (formerly included in). Unlike other similar drugs (drugs), it does not enhance gastrointestinal motility, but only blocks nerve receptors that cause nausea.

The drug is produced in 2 forms:

1. 
   Solution

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   . 1 ml contains 10 mg of the active substance - maropitant citrate, and auxiliary components: sodium β-cyclodextrin sulfobutyl ether (63 mg), water for injection (up to 1 ml). Packaged in 20 ml bottles, the average cost of one is 4,700 rubles.

2. 
   Pills

   . Includes the main active ingredient maropitant citrate and auxiliary ingredients: magnesium stearate, lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, dye E110. Capsules are packaged in aluminum blisters of 4 pieces.

Tablets are produced in 4 dosages:

• 16 mg – average price 210 rubles;
• 24 mg – 275 rubles;
• 60 mg – 385 rubles;
• 160 mg – 870 rubles.

What is the most important information a dog owner should know about Serenia?

Dogs should not be fed for at least 1 hour before administration of Serenia.

To prevent acute vomiting, Serenium can be given once a day for up to 5 days. To prevent vomiting due to motion sickness, the drug can be given once a day, 2 hours before travel, for up to 2 days in a row. Do not place tablets containing the drug in hot dogs, sausages, or hard cheese, as this may reduce effectiveness due to delayed absorption. If necessary, wrap the tablet in a small amount of food, such as deli meat.

Answers to frequently asked questions

Can an opened drug be used?

Sereniya does not lose its properties when properly stored. Thus, the tablet removed from the blister can be used within 2 days. And the solution, after the first withdrawal from the bottle, lasts for 3 months: the main thing is, after piercing the lid, close it with adhesive tape and store at a temperature of 3-25°C.

Can a puppy dog ​​have Serenia?

No, the drug is prohibited for pregnant and lactating bitches, as it is harmful to fetuses and newborn puppies. But a veterinarian can prescribe drugs if the pet’s life is at risk and other medications do not help.

Planning a train trip for several days with your dog? Can I give her the pills all the time?

You can’t: in this case, the drug accumulates in the body. It is allowed to feed a maximum of 2 tablets in a row for 2 days, after which a break is needed for 72 hours. In addition, the medication lasts for at least 12 hours, so there is no need to continuously give the animal pills.

The dog is vomiting severely. What is better: giving an injection or giving a pill?

In case of prolonged, profuse vomiting, it is better to give an injection: it will act 2-3 times faster. In addition, the dog may vomit the tablet during the next attack.

How should Serenia be given to dogs?

Give the medication exactly as directed by your veterinarian. If you do not understand these directions, ask your pharmacist or veterinarian to explain them to you. To prevent motion sickness, Sereniya should be given 2 hours before travel, but you should not feed your pet for at least 1 hour before giving Sereniya. Your veterinarian may require blood tests or other medical tests to monitor your pet's condition. Store the drug at room temperature in a dry place. Keep this medication out of the reach of children and other pets.

Contraindications and side effects

There are not many contraindications to taking Serenia, so this drug is often prescribed by veterinary specialists. You cannot give medicine:

• pregnant cats, since the effect of its active substance on the fetus has not been studied;
• kittens under the age of four months;
• in case of individual intolerance to the active component.

Side effects of Serenia manifest themselves in the form of allergic reactions, which are easily relieved with the help of antihistamines.

What are the possible side effects of serenia in dogs?

If any of the following serious side effects occur, stop giving the drug and seek emergency veterinary medical attention: allergic reaction (difficulty breathing, swelling of the lips, tongue, or face; hives); sudden onset of diarrhea; vomit; shock; convulsions; coma. Other less serious side effects may occur. Side effects other than those listed in this leaflet may occur. Talk to your veterinarian about any side effects that seem unusual or particularly bothersome to your pet.

Analogues of the drug

Sereniya is a unique drug. There are no other medications that would only affect nerve impulses and not affect the functioning of the digestive system. And among veterinary drugs, only Reisfit can replace the development from Zoetis. In other cases, dogs are given medicine for humans.

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Sereniya injection solution

The only remedy for stopping vomiting of any origin, designed specifically for dogs and cats.

Packaging: Bottle 20 ml

Composition: As an active ingredient, Sereniya injection solution contains 10 mg maropitant per 1 ml.

Indications for use: Sereniya is used to prevent vomiting of various origins in dogs and cats.

Dosage: The drug is administered to dogs and cats subcutaneously at a dose of 1 mg per kg of animal weight, which is equivalent to 1 ml of the drug per 10 kg of animal weight, once a day for no more than 5 days in a row.

Instructions #

on veterinary use of the drug Serenia

(Developer organization: Zoetis Inc, 10 Sylvan Way, Parsippany, New Jersey 07054, USA)

I. General information

1. Trade name of the medicinal product: Cerenia. International nonproprietary name: maropitant. 2. Dosage form: solution for injection. Sereniya contains in 1 ml the active substance maropitant (in the form of maropitant citrate) - 10 mg and excipients - metacresol, sodium sulfobutyl ether /3-cyclodextrin and water for injection. 3. In appearance, the drug is a transparent liquid of light yellow color. The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of manufacture. After selecting part of the drug from the bottle, subject to aseptic rules and specified storage conditions, it can be used repeatedly for 90 days. Do not use Sereniya after the expiration date. 4. The drug is released packaged in 20 ml glass bottles, sealed with rubber stoppers reinforced with aluminum caps. The bottles are packed in individual cardboard boxes. Each box of the drug contains instructions for its use. 5. Store the drug in the manufacturer’s sealed packaging in a place protected from direct sunlight, separately from food and feed at a temperature of 2 °C to 25 °C. 6. The drug should be stored out of the reach of children. 7. Unused medicinal product is disposed of in accordance with legal requirements. 8. The drug is dispensed without a prescription from a veterinarian.

II. Pharmacological properties

9. Pharmacotherapeutic group: gastrointestinal drugs. 10. The active substance of the drug, maropitant, is an antagonist of neurokinium receptors (NK1) and inhibits the binding of substance P, a neutropeptide of the tachykinin group in the central nervous system. Maropitaitis is effective against vomiting of both central and peripheral origin. Maropitant is rapidly absorbed after subcutaneous administration and reaches maximum blood concentrations within 45 minutes. The bioavailability of the drug is 90%. Maropitant is more than 99% bound to plasma proteins. Maropitant is metabolized in the liver by cytochrome P450 and is excreted primarily in feces. In terms of the degree of impact on the body, maropitant is classified as a moderately hazardous substance (hazard class 3 according to GOST 12.1.007-76).

III. Application procedure

11. The drug is used to prevent vomiting of various origins in dogs and cats. 12. The use of the drug in dogs under 8 weeks of age, cats under 16 weeks of age and animals with increased individual sensitivity to the components of the drug is prohibited. The drug should be prescribed with caution to animals with liver pathology and in cases of heart failure. 13. When working with the drug Sereniya, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicinal products. When working with the drug, it is forbidden to drink, smoke, or eat. After finishing work, wash your hands with warm water and soap. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with the drug. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label). Empty drug bottles must not be used for household purposes; they must be disposed of with household waste. 14. The drug is not recommended for use by pregnant and lactating females. 15. The drug is administered to dogs and cats subcutaneously or intravenously at a dose of 1 mg/kg of animal weight, which is equivalent to 1 ml of the drug per 10 kg of animal weight, once a day for no more than 5 days. 16. When using the drug in accordance with the instructions, side effects and complications, as a rule, are not observed. If allergic reactions occur, stop using the drug and prescribe antihistamines and symptomatic treatment. When administered, a painful reaction is possible, especially in cats. 17. Symptoms of drug overdose have not been established. 18. Serenia can be used as part of complex therapy with other pathogenetic agents. The drug should not be co-administered with calcium channel blockers as maropitant has an affinity for calcium channels. Maropitan may compete with drugs that are highly bound to plasma proteins. 19. No specific effects were identified upon initiation of administration and discontinuation of the drug. 20. Omissions should be avoided when administering the next dose of the drug, as this may lead to a decrease in effectiveness. If one dose is missed, the course of treatment should be resumed in the doses and dosage regimen prescribed in the instructions. 21. The medicinal product is not intended for use in food-producing animals.

Names and addresses of production sites of the manufacturer of the medicinal product for veterinary use: FAREVA AMBOISE, 3.I. d'Amboise F 37530 Poce-sur-Cisse, France/ FAREVA AMBOISE, ZI d' Amboise F 37530 Poce-sur-Cisse, France. Zoetis Manufacturing and Research Spain, S.El., Ctra. Camprodon s/n “La Riba” 17813 Ball de Bianya, Girona, Spain / Zoetis Manufacturing & Research Spain, SL Ctra. Camprod6n s/n “la Riba” 17813 Vall de Bianya Girona, Spain

Name, address of the organization authorized by the holder or owner of the registration certificate of the medicinal product to accept claims from the consumer: Zoetis LLC, RF, 123112, Moscow, Presnenskaya embankment, 10.

In what cases is it prescribed

Veterinarians usually prescribe graying in the following situations:

• cystitis;
• diseases of the gastrointestinal tract;
• severe intoxication of the body;
• cancer;
• when rocking a cat (when transporting by car);
• when undergoing a course of chemotherapy procedures;
• chemical poisoning;
• helminth infection;
• accumulation of hair in the stomach or esophagus;
• intestinal obstruction.

Burps with hairballs

Storage conditions

The instructions for the veterinary drug "Sereniya" for cats and dogs indicate that the shelf life is three years from the date of manufacture. After opening the package, you can store the medicine for no more than 48 hours. The medication package should be placed away from sunlight and food, and out of the reach of animals and children. The drug should be stored in a cool and dry space, at a temperature not exceeding plus 30 degrees. Unused medicine must be disposed of after the expiration date.

Injecting at home video

Pills

All owners give tablets to cats in different ways, since there is no single option on how to do this. Now we will tell you about the main ways to take medications in tablet form.

1 way

1. Wear disposable gloves.
2. Remove the serenia tablet from the blister.
3. Place the cat on your lap, preferably with the cat's muzzle located above body level.
4. Open your pet's mouth and place the tablet on the root of your tongue with your other hand. Thanks to the swallowing reflex, he will swallow on his own.

Method 2

1. Grind 1 piece and then stir in 5-10 ml of warm boiled water.
2. Draw the resulting solution into a syringe without a needle.
3. Ask your loved ones to hold the mustache.
4. Open its mouth with one hand and inject the suspension with the other. It is very important to spray the product directly onto the palate, in which case the medicine will definitely enter the esophagus.

3 way

1. Crush the Serenium tablet.
2. Take a small portion of food (minced meat, canned cat food or pate (chicken or goose liver) are great).
3. Add the resulting powder to your food and mix well.
4. Give your cat a bowl of food and make sure he eats everything. You should not leave the leftovers in the bowl as it will spoil after a few hours.
5. After this, you need to wash the bowl with detergent.

How much does it cost and where to buy

"Serenia" is considered a fairly common medicine. It can be purchased at almost any online store or veterinary pharmacy. The medicine is quite expensive.

The price of a 20 ml bottle starts from 4,000 rubles, and a package with four tablets starts from 1,000 rubles. Considering that the medicine is original and has no analogues on the Russian market, the high cost is justified by the effectiveness of the medicine.

How it affects the body

When it enters the cat’s body, thanks to the circulatory system, the active substance quickly spreads throughout the body. The active substance (maropitant citrate) is able to effectively block receptors at the peripheral and central levels of the central nervous system.

Therefore, in cats, the unpleasant gag reflex is suppressed, and accordingly, vomiting and nausea stop.

Injections act approximately 2 times faster compared to tablets. This is due to the fact that maropitant citrate immediately binds to plasma proteins and spreads throughout the cat’s body.

Owner reviews

Christina: I used the drug Sereniya 2 times, because the kittens often vomited when moving. And after using the product, such consequences disappear. I advise everyone to buy only in syringes, they are only 1-2 ml. If you buy a whole 20 ml bottle, then most likely you will waste money. Since an open bottle is stored for 1 month.

Olga: My cat was diagnosed with acute cystitis during an examination at the clinic. This disease caused great pain to my pet, she also vomited often, and she did not eat at all. The veterinarian recommended the drug sereniya, as it should stop all vomiting. I used to have a cat, and I gave him injections, so I chose the injection form because it works faster. By evening the pet felt better and the nausea stopped. Therefore, I was even able to give her milk. No adverse reactions were identified, they can recommend a remedy!